Rabbit internal dosimetry for iodine-131 using GATE Monte Carlo simulation code: a preclinical trial

Authors

  • Maryam Fallahpoor Department of Nuclear Medicine, Vali-asr Hospital Tehran University of Medical Sciences, Tehran, Iran
  • Mehrshad Abbasi Department of Nuclear Medicine, Vali-asr Hospital Tehran University of Medical Sciences, Tehran, Iran
  • Parham Geramifar Department of Nuclear Medicine, Shariati Hospital Tehran University of Medical Sciences, Tehran, Iran
  • Shima Yavari Department of Nuclear Medicine, Vali-asr Hospital Tehran University of Medical Sciences, Tehran, Iran
Abstract:

Introduction: One of the main concerns in administration of radiotracers, especially in therapeutic arm, is the amount of delivered dose to the different organs. Individual variations of anatomy, physiology and underlying pathology in the patients lead to alteration of administered activity. In the current study we preclinically applied internal dosimetry using an animal model   Materials and Methods: The SPECT/CT imaging of a rabbit 24 hours after administration of 288μci Iodine-131 was done. Biodistribution of radiotracer was obtained from SPECT, and the CT was used to define attenuation map and the target volume of interest (VOIs). Dosimetry calculations were performed with GATE Monte Carlo code and S-values for beta and gamma radiation of different organs were calculated.   Results: The S-values of thyroid as target organ are 1.09×10-4(mGy/MBq/sec) for beta and 1.05×10- 5 for gamma radiation. And S-values of kidneys, lungs, spine, and heart as critical organs are 1.10×10-5, 1.58×10-5, 7.62×10-6, 6.75×10-6 for beta, respectively and 3.9×10-6, 2.69×10-6, 2.63×10-6, 3.27×10-6 for gamma, respectively Conclusion: The internal dosimetry is applicable clinically. The response to therapy would be increased and the side effect would be minimized if the prescription using patient specific dosimetry is optimized.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

monte carlo simulation of a 6 mv x-ray beam for open and wedge radiation fields, using gate code

the aim of this study is to provide a control software system, based on monte carlo simulation, and calculations of dosimetric parameters of standard and wedge radiation fi elds, using a monte carlo method. gate version 6.1 (opengate collaboration), was used to simulate a compact 6 mv linear accelerator system. in order to accelerate the calculations, the phase-space technique and cluster compu...

full text

A review of the use and potential of the GATE Monte Carlo simulation code for radiation therapy and dosimetry applications.

In this paper, the authors' review the applicability of the open-source GATE Monte Carlo simulation platform based on the GEANT4 toolkit for radiation therapy and dosimetry applications. The many applications of GATE for state-of-the-art radiotherapy simulations are described including external beam radiotherapy, brachytherapy, intraoperative radiotherapy, hadrontherapy, molecular radiotherapy,...

full text

Bayesian internal dosimetry calculations using Markov Chain Monte Carlo.

A new numerical method for solving the inverse problem of internal dosimetry is described. The new method uses Markov Chain Monte Carlo and the Metropolis algorithm. Multiple intake amounts, biokinetic types, and times of intake are determined from bioassay data by integrating over the Bayesian posterior distribution. The method appears definitive, but its application requires a large amount of...

full text

Comparison of dosimetry parameters of two commercially available Iodine brachytherapy seeds using Monte Carlo calculations

Background: Iodine brachytherapy sources with low photon energies have been widely used in treating cancerous tumors. Dosimetric parameters of brachytherapy sources should be determined according to AAPM TG-43U1 recommendations before clinical use. Monte Carlo codes are reliable tools in calculation of these parameters for brachytherapy sources. Materials and Methods: Dosimetric param...

full text

Radioiodine (131-I) treatment for Graves’ disease: Geant4 Monte Carlo simulation for patient personalized dose estimation

Background: Reliable estimation of radiation-absorbed dose is necessary to evaluate the benefits and the risks of radiopharmaceuticals used for diagnostic or therapeutic purposes in nuclear medicine. Materiel and Methods: This study included 47 patients treated with iodine-131 for Graves’ disease. A comparative study between Geant4 Monte Carlo simulation and MIRD formalism was carried out to ev...

full text

Dosimetry, scattering theory, and Monte Carlo simulation

The purpose of this paper is to provide an introduction to the physics of scattering theory, to define the dosimetric concept of linear energy transfer in terms of scattering theory, and to provide an introduction to the concepts underlying Monte Carlo simulations.

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 15  issue Special Issue-12th. Iranian Congress of Medical Physics

pages  236- 236

publication date 2018-12-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023